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Biomarker is a indicator that can detect changes in biological state or condition of the body using cells, blood vessels, proteins, or DNA, etc. The first use of the word biomarker is the National Institutes of Health (NIH), which defines biomarkers as "a defined characteristic that is used as an indicator of normal biological processes, pathogenic processes or responses to a therapeutic intervention" . JW is currently accelerating the development of the kit by securing unique technologies for sepsis diagnostic biomarkersand pancreatic cancer diagnostic biomarkers.

WRS, promising biomarker for sepsis

Tryptophanyl tRNA synthetase(WRS) is one of aminoacyl tRNA synthetases and has two forms – full length WRS (FL-WRS) and mini length WRS (mini-WRS, N-truncated form). In vitro study shows that FL-WRS could promptly trigger innate immunity against infection and be released immediately without de novo synthesis. In vivo study shows that WRS increases earlier than other sepsis biomarkers, such as procalcitonin and interleukin-6. Clinical trial shows that (1)WRS is superior to other biomarkers in terms of differentiating sepsis from inflammation, (2)the level of WRS could help to stratify the severity of the septic condition.

  • Secreted tryptophanyl-tRNA synthetase as a primary defence system against infection Nature Microbiology 2016 OCT :191
  • Clinical value of full-length tryptophanyl-tRNA synthetase for sepsis detection in critically ill patients — A retrospective clinical assessment International Journal of Infection Diseases 2020 May (97):260-66
Intellectual property
  • Composition and method for detecting a diagnostic marker for infectious disease or infectious complications using tryptophanyl-tRNA synthetase (2016)
    - Korean Patent Registration Completed (10-1771697)
    - U.S./European/Japanese/Chinese patent registration complete
  • Antibodies specifically binding to WRS protein and uses thereof (2019)
    - Korean Patent Registration Completed (10-2478445, 10-2489531)
    - US/Europe/Japan/China application completed, under review
1) Curr Opin HIV AIDS. 2010 Nov; 5(6): 463–466.
Combination of CFB and CA19-9, novel biomarker for pancreatic cancer

Complement factor B(CFB) is known to play an important role in the alternative pathway of complement system. JW is underdevelopment of multi-biomarker diagnostic kit using CFB and CA19-9 which pancreatic cancer can be detected in early stage through a simple blood test.

Diagnostic Values of CA 19-9 and CFB According to Cut-off Levels in PC versus Other Disease
CFB (ng/mL) CA 19-9 (U/mL) CFB1 + CA 19-9
PC vs Others 78.42 37 -
Y-index 71 50.4 87.4
(%; 95% CI)
(%; 95% CI)

1Sensitivity and specificity of the combination of CFB and CA 19-9 from the maximum Youden’s index.
2Predicted optimal cut-off value from the maximum Youden’s index.
Abbreviations: CA19-9: carbohydrate antigen 19-9; CFB: complement factor b; PC: pancreatic cancer; Others: HD (healthy donor), CP (chronic pancreatitis), HCC (hepatocellular carcinoma), CC (cholangiocarcinoma), GC (gastric cancer)


Identification of Human Complement Factor B as a Novel Biomarker Candidate for Pancreatic Ductal Adenocarcinoma J Proteome Res. 2014 Nov 7;13(11):4878-88

Early Diagnostic Ability of Human Complement Factor B in Pancreatic Cancer Is Partly Linked to Its Potential Tumor-Promoting Role. J Proteome Res. 2021;20(12):5315-5328.

Intellectual property
  • Pancreatic cancer diagnostic kit including antibody that specifically binds to complement factor B protein (Registration No. 10-1594287)
  • Patent registered in KR/EP/JP/CN/US



POCT (Point of Care test)

JW Bioscience is developing an easy to use, bench-top chemiluminescent immunoassay analyzer providing high-quality results from blood samples within 20 minutes.

  • Compact immunoanalyzer with full automation
  • High level of accuracy from combination of chemiluminescence technology
  • Single test reagent cartridge
  • Six simultaneous tests in under 20 minutes




- Immunoassay is an biochemical test that measures the target analyte (ex. Protein) using antigen-antibody responses. Immunoassay can be used to diagnose diseases such as cancer, infectious diseas and immune disorders, and so on.
- JW has antibody screening technology for select, antibody candidates for biomarkers, and optimizing immunoassay methods using a variety of buffers and substrates.